Billionaire-Backed Startup Plans to Create 'Organ Sacks' as Alternatives to Animal Testing

Billionaire-Backed Startup Plans to Create ‘Organ Sacks’ as Alternatives to Animal Testing

As the Trump administration concludes the use of animal testing within the federal government, a biotech startup is suggesting a novel alternative: nonsentient “organ sacks.” R3 Bio, located in the Bay Area, is pitching this concept to investors and industry publications as a means to substitute lab animals without ethical dilemmas. These constructs would contain all organs except a brain, rendering them incapable of cognition or experiencing pain. Cofounder Alice Gilman states the aim is to develop human equivalents for tissue and organ transplantation. Immortal Dragons, a fund based in Singapore, regards this as a longevity strategy, prioritizing replacement over repair. R3 intends to create monkey organ sacks for more ethical and scalable testing. Monkeys, which are essential yet diminishing resources for drug testing, particularly during Covid-19, are experiencing a decline in availability across the U.S. The shift toward less animal testing is driven by animal rights advocates and federal actions. Organ sacks could become essential as research monkeys become increasingly scarce, providing benefits over existing models that lack comprehensive organ complexity. Gilman mentions they can produce mouse organ sacks without a brain but refrains from confirming their creation. The company is investigating the application of stem-cell technology and gene editing to develop monkey and human organ sacks. According to Paul Knoepfler, a stem cell biologist at UC Davis, organ sacks could originate from induced pluripotent stem cells, which are reprogrammed adult skin cells capable of transforming into any type of body tissue. Scientists could inactivate brain development genes and cultivate embryos into organ structures.

Don’t Pay Attention to Those Who Believe Secession Will Resolve Any Issues

Don’t Pay Attention to Those Who Believe Secession Will Resolve Any Issues

Following startling national incidents such as the assassination of Charlie Kirk or Donald Trump’s military actions in Los Angeles, discussions of “civil war” and secession calls rise sharply on the internet. This trend reemerged in January when immigration officials shot two citizens in Minneapolis, leading governor Tim Walz to activate the Minnesota National Guard. Walz wondered if this could be a Fort Sumter moment during a conversation with The Atlantic. In the meantime, ex-Minnesota governor Jesse Ventura proposed the idea of leaving the US to unite with Canada.

These remarks illustrate the discourse surrounding American fragmentation: an escalating civil war as a dreadful scenario, and a neat secession as an idealistic vision. But is one feasible without the other, and what would secession from the US encompass?

Since the 1990s, certain futurists from Silicon Valley have forecasted the disintegration of the American nation-state without outlining the horrific aspects. The mid-2000s concept splitting North America into a blue “United States of Canada” and a red “Jesusland” endures, and rising polarization has led many to consider secession as a viable resolution. “We require a national divorce. We need to split between red states and blue states,” wrote then-congresswoman Marjorie Taylor Greene in 2023.

Coordinated independence movements such as Calexit and the Texas Nationalist Movement have gained momentum, with a 2023 Axios survey revealing that 20 percent of Americans advocate for a “national divorce.” A YouGov survey indicated that 61 percent of Californians believed their state would thrive better if it seceded peacefully after Trump’s second inauguration.

The challenge of secession lies in its harrowing pathway. Half of all secessionist efforts escalate into violence. Successful non-violent secession, like Czechoslovakia’s Velvet Divorce, depends on nationally unique, regionally concentrated populations with governmental recognition, none of which currently characterize the US.

The red and blue segments of America are deeply interwoven, with political divisions permeating states, neighborhoods, and even family units. An ideologically motivated secession would necessitate a perilous reorganization of Americans. Establishing a new coherent map would pose significant challenges, resulting in security dilemmas and refugee crises, akin to the situations in India and Pakistan in 1947 and Cyprus in 1974, likely to unfold in America as well.

Premium Merino Wool Apparel (2026): Base Layers, Hooded Sweatshirts, Coats & Additional Options

Premium Merino Wool Apparel (2026): Base Layers, Hooded Sweatshirts, Coats & Additional Options

Merino wool is an exceptional fiber. The highest quality merino wool garments can be warm in 95-degree heat, while merino base layers provide insulation in freezing temperatures. In contrast to synthetic fibers derived from petroleum, merino wool is both natural and eco-friendly.

Merino wool’s versatility leads to a wide range of blends and choices. Below are our favorite merino wool items, evaluated through wearing and washing (commonly in cold water and hung to dry, although we also machine dry them for testing purposes) over months or even years. Once you finish reading, dive into our other apparel guides, such as the Best Merino Wool T-Shirts, Best Base Layers, Best Puffer Jackets, Best Hoodies, and Best Hiking Boots.

Updated April 2026: Our top recommendation for boxers is now Wool & Prince, and we have added more hoodies along with the Ibex women’s Goat short sleeve. Prices and links have been refreshed throughout.

Why Is Merino Wool So Wonderful?

Merino wool is remarkable as it replicates a sheep’s capacity to manage temperature in response to the environment, also referred to as thermoregulation. If your experience is limited to scratchy wool sweaters from your proverbial grandmother, you may find the enthusiasm puzzling. Merino sheep have finer, softer wool, evolved to maintain comfort in varying temperatures, making it a delight to wear against your skin. Wool is sustainable as well.

A single sheep can produce 4 to 5 pounds of wool annually. Merino sheep indeed possess softer wool, which makes merino wool an extraordinary fabric that has become a staple in wardrobes.

What Does GSM Stand For?

Merino wool is available in various weights, often marked as “200 gsm” or similar. GSM signifies grams per square meter, occasionally shown as g/m. Generally, T-shirts and underwear are around 150 gsm, with some falling as low as 120 gsm. Typically, anything under 200 gsm is suitable for a base layer or T-shirt. Weights ranging from 200 to 300 gsm are considered mid-layers, while anything above 300 is categorized as heavier.

If you understand synthetic ratings akin to those used for fleece, around 120–160 gsm wool is comparable to 100-weight fleece, 160–200 gsm matches 200-weight fleece, and anything over 200 corresponds to 300-weight fleece. Wool retains warmth better because it is more effective at trapping heat, particularly in windy conditions, although there are scenarios where fleece is favored for its lightweight characteristics.

What Is Nuyarn?

Nuyarn is a blend of merino wool and synthetic materials, where merino wool envelops a nylon core to provide warmth, lightness, and durability. The goal is to take advantage of merino’s temperature management and nylon’s resilience. Nuyarn is particularly effective for base layers, although for casual use, 100% wool is often the preferred choice.

How to Maintain Merino Wool

Typically, merino products include care guidelines, often recommending cold washing and flat drying. Hanging wool can cause it to stretch due to the weight of water. While most labels permit machine washing, hand-washing prolongs the lifespan of the garment, particularly for lighter base layers and T-shirts. The exception is Minus33’s Microweight Raglan short sleeve T-shirt, which is both machine washable and dryer-friendly, having maintained its quality after a year of both wash methods.

There are no issues storing merino in a closet between wears, but for long-term keeping, measures against moths are essential, as they can damage wool. Wash and thoroughly dry any items you store, then seal them in a compression bag. As an alternative, you can use a cotton bag in a plastic bin, ensuring the garment is dry to avoid mold. Other storage solutions include a cedar chest, moth traps, or lavender sachets as repellent options.

100 Percent Merino vs. Blends

When choosing between 100% merino or a blend, it hinges on the garment, its purpose, and your preferences. Blends provide stretch, which is excellent for active activities like hiking or rock climbing. 100% merino is preferred for heavier mid-layers like hoodies or jackets, while blends are more effective for lighter layers. The closer a layer is to your skin, the more likely a blend is the better choice, with Nuyarn being a leading option for base layers.

Alpaca blends are also incredibly soft, though pricier, presenting an alternative for those allergic to lanolin in merino, as alpacas do not produce it, resulting in a softer and warmer fabric.

Merino vs. Synthetic Fibers

Which is superior? It varies, but often merino comes out on top. Synthetics generally excel at wicking moisture away, feeling drier and drying more quickly, particularly in socks and underwear where “merino” options usually contain over 50% synthetic materials. Nonetheless, synthetics tend to hold onto odors, whereas merino tends to resist them more effectively.

Breathability is another distinguishing feature—synthetics have acceptable breathability, but merino performs exceptionally well, mitigating sweat cooling when in the shade. Durability also varies;

The Initial AirPods Max: Discount of $100

The Initial AirPods Max: Discount of $100

Apple has recently launched the AirPods Max 2, but the enhancements haven’t particularly wowed us, especially considering that the original version has undergone only minor alterations in the last five years. If the newest model doesn’t catch your interest, you might want to grab the original AirPods Max with USB-C at Best Buy for just $450, reflecting a $100 reduction. This offer could make the newer version seem redundant.

Even after being available for some time, the AirPods Max still rank among our favorites for noise-canceling over-ear headphones, perfect for iOS users looking to step up from basic earbuds. They boast a solid build with stylish aluminum ear cups, a distinctive design, and an array of vibrant color choices. While they are somewhat heavier, they excel in both luxury and comfort, with a conveniently located multifunction volume knob on the right ear.

Their audio performance is as impressive as their striking appearance. Since their introduction in 2020, our reviewer Parker Hall stated they are “the best noise-canceling headphones I have ever tested,” praising their exceptional noise cancellation and transparency modes, easy setup, and extensive feature range. Even when put side by side with labels like Sony and Bose, they are recognized for their clarity, intricate sound, and powerful bass. They also provide high-resolution wireless audio—a feature that’s uncommon in headphones.

Nonetheless, there are some drawbacks. The battery life, though sufficient for a lengthy flight at around 20 hours, falls short compared to some rivals. Furthermore, users who aren’t on iOS or macOS will experience a limited selection of features and should consider other recommended headsets. However, for iPhone users ready to make a purchase, Best Buy has various colors on sale, including Midnight, Blue, Purple, and Starlight.

Meta Is Shutting Down Horizon Worlds on Meta Quest

Meta Is Shutting Down Horizon Worlds on Meta Quest

Meta has revealed the closure of its virtual reality platform, Horizon Worlds. An email sent to users indicated that the social VR universe will cease operations on Quest VR headsets, with Horizon Worlds being taken off the Quest store on March 31. By June 15, the VR environments will be fully discontinued, shifting the service to a mobile-only platform. This move comes after substantial reductions to Meta’s Reality Labs division earlier this year, which experienced a 10% decrease in VR department personnel.

Horizon Worlds was Meta’s bold initiative to create the metaverse, inspired by Neal Stephenson’s “Snow Crash.” The project was pivotal to Meta’s rebranding from Facebook to concentrate on virtual reality pursuits. However, Horizon Worlds encountered backlash and tepid popularity, evident in the reactions to its termination on the r/oculus subreddit. It was frequently ridiculed for its initial flaws, such as avatars without legs and their “blank-eyed” look, spawning viral memes featuring CEO Mark Zuckerberg’s avatar.

At first, Horizon Worlds mainly attracted younger users, resulting in an inconsistent user base, despite Meta’s significant financial backing and initiatives, including virtual concerts with famous artists like Imagine Dragons and Coldplay. Still, Meta’s platform was less favored than alternatives like VRChat, which cultivated communities through virtual parties and events.

As Meta redirects its attention to AI and products like Ray-Ban smart glasses, it has notably curtailed investments in its metaverse initiatives, including offerings like Supernatural Fitness. Mike Proulx from Forrester noted that this shift was anticipated and emphasized the challenges of constructing a mass social platform dependent on specific hardware that lacks broad user adoption.

Sonos Over-Ear Headphones: Get $100 off

Sonos Over-Ear Headphones: Get $100 off

If your residence is equipped with Sonos devices, you may want to consider acquiring a pair of over-ear headphones that effortlessly connect to your speakers. Sonos provides such a pair, the Ace, currently listed at $299 on Amazon, nearly matching its lowest historical price.

These headphones not only work with your Sonos configuration via Bluetooth but also perform excellently on their own. Renowned for a clear, flat sound profile, the Ace manages tracks with prominent bass lines and delivers impressive detail with dynamic audio. Weighing in at only 11 ounces, they rank among the most comfortable, offering a suitable clamping force that alleviates pressure from your head, making them perfect if comfort is essential.

The Active Noise Cancellation (ANC) rivals the top options available, effectively controlling low-frequency noises. The transparency mode provides clear conversations, eliminating the sensation of speaking through a tin can. Although they lack some convenience features, they do offer multipoint pairing, and you can adjust settings through the Sonos app.

The Sonos Ace comes in several colors, but the black version is currently priced at $300. The white variant is available for $365, slightly higher, depending on your color preference. If the Sonos Ace doesn’t catch your interest, our detailed guide to the best headphones, evaluated by audio specialists, presents additional choices.

File Your Taxes Today With TurboTax Full Service Before Costs Go Up

File Your Taxes Today With TurboTax Full Service Before Costs Go Up

Tax Day is scheduled for April 15 this year, allowing you under a month to file without incurring penalties or requiring an extension. The longer you wait, the higher the cost of using a tax service, and if you’re like me with intricate taxes, you may have delayed. Take this as your reminder to file immediately. TurboTax has a promotion for combined federal and state filing at $150 for Expert Full Service for new clients, valid until March 18.

TurboTax provides three options: DIY, where you file with step-by-step guidance; Expert Assist, where professionals aid and review your submission; and Expert Full Service, where a local specialist finalizes your taxes. Fees vary based on your tax scenario, with Expert Full Service starting at $89 to $129, plus $59 for each additional state. For those facing complicated taxes, this fixed fee arrangement can yield savings.

Small business owners or individuals with intricate taxes might find Expert Full Service a valuable option, particularly for S Corporations and partnerships. TurboTax pairs you with a tax specialist experienced in your sector to enhance deductions. You can opt to manage your taxes online or in person, and the expert will finish, sign, and submit your taxes. The $150 charge is only incurred after the filing.

This promotion is valid only if TurboTax did not file your taxes last year. The ultimate cost will depend on the complexity of your situation, with states billed separately. To take advantage of this offer, begin filing using TurboTax Expert Full Service or choose “prefer to hand off to an expert” when prompted. If eligible (i.e., you didn’t engage a TurboTax expert for a 2024 personal tax return), your discount will automatically apply at checkout if you file by March 18, 11:59 pm ET.

If you’re not sure which service is suitable for you, refer to the guide on How to Pay Your Taxes Online or this year’s Best Tax Services guide. If you’re contemplating TurboTax but uncertain about the right tier for you, I sampled TurboTax’s DIY service and discovered various TurboTax coupons, which might help save money when submitting your taxes.

John Solly: The DOGE Agent Charged with Scheming to Shift Social Security Information to His New Position

John Solly: The DOGE Agent Charged with Scheming to Shift Social Security Information to His New Position

John Solly, a software developer and previous member of the Department of Government Efficiency (DOGE), is allegedly reported to have informed colleagues that he had kept critical Social Security Administration (SSA) data on a USB drive with plans to present it to his new employer, as per sources. Since October, Solly has held the position of chief technology officer for Leidos’ health IT sector, which possesses substantial contracts with SSA. Solly’s online footprint has been erased this week. Through his legal representation, Solly refutes any accusations of misconduct. Leidos has found no proof that supports the whistleblower’s allegations. Solly was a member of a 12-person DOGE team at SSA, contributing to various projects. A report, not specifying Solly or Leidos, was submitted to the SSA’s Inspector General, claiming that a former DOGE employee had taken SSA data to possibly use at a private-sector firm, anticipating clemency for any illegal acts. Solly asserts that he did not partake in the alleged conduct. Leidos stands as a prominent SSA contractor, continuing to gain substantial contracts despite cuts under DOGE’s initiatives.

How 'Handala' Emerged as the Symbol of Iran's Cyber Counteractions

How ‘Handala’ Emerged as the Symbol of Iran’s Cyber Counteractions

In the wake of the extensive airstrike operations conducted by the United States and Israel over Iran in late February, the cybersecurity sector anticipated retaliatory cyber offensives targeting Western entities. Tuesday night saw such an incident unfold in the US: a data breach at the medical technology company Stryker, believed to have ties to Iran, disabled tens of thousands of computers and disrupted global operations. The Iranian hacking collective Handala took responsibility for the breach.

A pronouncement on Handala’s website characterized the cyber operation as a reaction to the American Tomahawk missile assault that claimed the lives of 165 civilians at a girl’s educational institution in Iran and the ongoing hacking actions of the US and Israel. This pronouncement marks the beginning of a new phase in cyber warfare.

Once relatively unknown, Handala—named after a character created by Palestinian artist Naji al-Ali—is regarded by cybersecurity analysts, particularly in Israel, as a façade for Iran’s Ministry of Intelligence. Renowned for its data-deletion and hack-and-leak strategies, its targets have included the Albanian government and Israeli organizations.

In light of escalating existential threats, Iranian hackers, chiefly Handala, are encouraged to use every intended tool and network access against the US and Israel, stated Sergey Shykevich from the cybersecurity firm Check Point. Shykevich identifies Handala as the most active and prominent group in this vengeful campaign.

While hacking collectives often inflate their achievements, Handala has claimed numerous victims, predominantly in Israel, throughout the recent hostilities. Merging chaotic hacktivist tactics with governmental capabilities, the group acts as a primary cyber-retaliation entity for Iran, according to Justin Moore from Palo Alto Networks’ Unit 42.

Despite the chaos it generates, Handala’s operational coherence is doubtful, according to Rafe Pilling from Sophos’ X-Ops team. The group attempts swift access and infliction of damage in reaction to airstrikes that reportedly impact Iran’s cyber capabilities. Currently, Handala seems to be exploiting any available opportunity without an evident strategic framework.

Apple's Newest MacBook Air and Pro Variants Showcase Advanced Chips, Expanded Storage, and Elevated Prices

Apple’s Newest MacBook Air and Pro Variants Showcase Advanced Chips, Expanded Storage, and Elevated Prices

Alongside its affordable iPhone 17e and M4 iPad Air announced on Monday, Apple has unveiled updates for the MacBook Pro, MacBook Air, and its infrequently updated desktop display line. It seems Apple is reserving its anticipated new entry-level MacBook for an in-person event in New York City on Wednesday, but today’s announcements are likely to please those looking to upgrade.

The MacBook Air now features the newest M5 chip. This is a somewhat minor enhancement but aligns it with Apple’s latest processor that was introduced in the MacBook Pro last autumn. There are no other major hardware changes—it now comes with 512 GB of base storage utilizing “faster SSD technology”—but buyers can still opt for a 13- or 15-inch display.

This laptop also includes Apple’s N1 wireless chip, supporting Wi-Fi 7 and Bluetooth 6, in line with the latest connectivity standards. It retains the standard 16 GB of RAM, though there’s a regrettable $100 price hike due to the extra storage. The starting prices are now $1,099 for the 13-inch variant and $1,299 for the 15-inch variant. Apple announces that pre-orders will commence on Wednesday, with sales starting on March 11.

More significantly, Apple is broadening the M5 chip family with the M5 Pro and M5 Max, now available in the 14-inch and 16-inch MacBook Pro. As with previous generations of Apple silicon, the “Pro” and “Max” versions deliver markedly improved multicore CPU and graphics performance.

The M5 Pro and M5 Max can be configured with up to 18 CPU cores (12 performance cores and 6 “super” cores), a boost from 16 on the M4 Max. The M5 Pro can be upgraded to include up to 20 GPU cores, while the M5 Max can go up to 40 GPU cores. Apple claims a 30 percent enhancement in multithreaded CPU performance for the M5 Pro compared to the M4 Pro. The M5 Max CPU upgrade is a bit more modest—just 15 percent higher than the M4 Max, according to Apple.

Thanks to higher memory bandwidth, a more efficient Neural Engine, and improved GPU architecture, Apple asserts that both the M5 Pro and M5 Max provide “over 4X the peak CPU compute for AI” compared to the last generation and deliver 20 percent better GPU performance.

The new MacBook Pros maintain the same hardware configuration that has remained unchanged since 2021—identical port options, Mini-LED display, speakers, and webcam. Even the reported 24-hour battery life remains stable with the M4 models, launched in late 2024. Notably, Bloomberg reported last week that Apple plans to introduce a more significant update for the MacBook Pro this year, expected to reveal the M6 chip, an OLED touchscreen, and a sleeker design.